Even as it tries to emerge from bankruptcy and eyes a possible merger with US Airways, American Airlines is busy with a new project: a face lift. The carrier unveiled its first new logo and aircraft livery in decades on Thursday, with brighter colors, an ?updated eagle? peeking out from a ribbon, a more contemporary font and bold red-white-and-blue stripes for its fleet?s tails.
The surging consumption of highly caffeinated energy drinks has triggered concerns about health risks for children and teens, but it turns out that adult drinkers could be more likely to end up in hospital emergency rooms.
More than 5,000 patients age 40 and older visited ERs due to health problems related to energy drinks in 2011, according to a new federal report -- a number that has tripled since 2007. Twin Cities ER doctors said they were not surprised, because the young energy drinkers of the past are now older energy drinkers with chronic conditions and diseases that don't mesh well with caffeine overloads.
"Adults in some ways do better [than teens] because they're more tolerant to the drug," said Dr. Jon Cole, an ER physician and medical director of the Hennepin Regional Poison Center in Minneapolis.
"On the other hand, as they get older, they have more underlying cardiac and neurologic disorders that could be exacerbated by it."
Nationally, the number of energy-drink-related ER visits doubled in four years, from 10,068 in 2007 to 20,783 in 2011, according to a report released Wednesday by the U.S. Substance Abuse and Mental Health Services Administration. Patients sought treatment for irregular or racing heartbeats, anxiety, seizures and other problems, and, overall, visits were most common among men aged 19 to 25.
The numbers in Wednesday's report tracked the rapid growth of energy drinks in recent years. Sales of Red Bull, for example, soared to 4.6 billion cans worldwide in 2011, with consumption rising 11 percent in the United States, 35 percent in France and 62 percent in Japan.
Rare but high-profile tragedies -- such as the death of a 14-year-old girl in Maryland who drank two large cans of an energy drink -- have drawn attention to the safety risks and brought calls from lawmakers to investigate the beverages and the accuracy of their ingredient lists.
The American Beverage Association, which represents energy-drink makers, said the federal report only counts patients in the ER who consumed energy drinks, and doesn't prove that energy drinks caused all of their symptoms, especially given the number of patients who took other substances. The organization says the products are safe and that many contain the same amount of caffeine as coffeehouse coffee.
'Sense of doom'
The increasing popularity of energy drinks -- which now fill entire banks of convenience stores with cans bearing the names Monster, Rock Star and Full Throttle -- prompted the Hennepin Regional Poison Center to track calls about people suffering health problems related to their consumption. The center reported 73 Minnesota cases since 2011, but no deaths.
Around the Twin Cities, adult drinkers expressed little surprise at the ER numbers, but suspected that they didn't involve regular consumers and instead involved novices who binged on them or took them with other substances. The federal report noted that 42 percent of the ER patients also had consumed alcohol or other drugs.
Brad Benson, 37, of Minnetonka said he has had "funny feelings" from too much caffeine, but not severe health problems from the combination of coffee, Mountain Dew and energy drinks that he consumes daily to work a late shift at night and help with his five kids during the day. "I'm so used to the amount of caffeine," he said, "that I don't really notice it anymore."
James Cave, 44, takes one low-carb Monster out of the fridge every day and cracks it open and sips it all morning in his history classroom at the Hmong College Prep Academy in St. Paul. Cave, who is raising six children, none of whom consume energy drinks, said his students notice if he tries a new flavor.
The Poison Center's Cole said energy drinks are a growing problem among adults and teens, but hardly at the level of prescription drugs and alcohol in terms of abuse and misuse.
Twin Cities ER doctors said patients who have overloaded on energy drinks show similar symptoms, and that asking about energy drinks has become almost automatic when teens report erratic or racing heartbeats.
"Someone will come up to the triage desk and say, 'I'm having palpitations or chest pains or shortness of breath or anxiety,''' said Dr. Jay Westwater, an ER physician at United Hospital in St. Paul. Cole said that in rare cases, patients report "this impending sense of doom. They feel like something terrible is going to happen to them and they have a hard time articulating it beyond that."
Brandy Boyer, 35, of Hastings said the worst health problems he ever experienced were the crushing headaches when he tried to quit energy drinks and all other forms of caffeine. He started taking them for an energy boost when he played semi-pro football a decade ago, and over time found them cheaper and tastier than gourmet coffee.
Boyer isn't sure if he drinks them for a caffeine surge anymore, or just for the habit. "I can't go a day without one," he said, "minimum."
Jeremy Olson ? 612-673-7744
If you've been trying to get your hands on a Nexus 4 (without signing a contract, anyway) then these past few weeks have probably been some pretty iffy ones. Even now they're unavailable from the Google Play store, but LG France Communications Director Cathy Robin wants to straighten things out a bit -- according to an interview with her in Challenges.fr, LG remains devoted to the Nexus 4 and pegs some of the supply woes on Google's questionable foresight.Source: http://feedproxy.google.com/~r/Techcrunch/~3/jNoAVbJDXwk/
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Source: http://www.delawareonline.com/article/20130115/SPORTS07/301150055/1028/rss0201
11:42 am, January 14, 2013
Local human resources company Sapience HR is hosting a seminar next week on managing change in small businesses.
The half-day session will provide business owners with an opportunity to check policies and procedures are up to date.
Topics covered will include the process of change, business growth, mergers and acquisitions, business reduction and managing staff.
For more details and to book a place on the event, which takes place on Wednesday January 23 at Carn Brea Leisure Centre?s Hub Club, click here.
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Jan. 14, 2013 ? Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away from a primary tumor and metastasize throughout the body. Their findings, published in Cancer Cell, suggest a novel approach for developing agents to treat cancer once it has spread.
"Metastasis can be lethal, and our findings point to potential targeted treatments to stop the spread of this aggressive breast cancer," says the study's senior investigator, Dr. Vivek Mittal, an associate professor of cell and developmental biology and director of the Lehman Brothers Lung Cancer Laboratory at Weill Cornell Medical College.
According to researchers, if such agents were developed, they would perhaps be the first to specifically treat cancer metastasis, importantly in patients whose tumors have already spread. They would also be among the first designed to restore the function of a microRNA (miRNA), a small, non-coding RNA that regulates gene expression, which is crucial to cancer spread. While distinct miRNA "signatures" have been found for many tumor types, including different breast cancers, their specific roles in later steps of cancer metastasis has been unclear, Dr. Mittal says.
In the study, researchers set out to identify a miRNA that impacts metastasis without affecting primary tumor growth, as well as address its underlying molecular mechanisms and therapeutic potential against metastatic breast cancer. They discovered that a miRNA known as miR-708 is inhibited in metastatic triple negative breast cancer. They found that miR-708 acts as a metastatic tumor inhibitor, and when its function is restored, the tumors do not spread or form lethal macrometastases.
Silenced miRNA Inhibitor Molecule Can Be Switched Back On
Triple negative breast cancer has the worst outcome of all breast cancer subtypes because of its high recurrence rate and metastatic spread. This is why the research team chose to examine the role of miRNAs in the spread of triple negative breast cancer, which accounts for 15-25 percent of all breast tumors. The cancer is named "triple negative" because its tumor cells do not display two hormone receptors (estrogen and progesterone) or HER2/neu growth factor, which each form the basis of current targeted breast cancer treatments.
Using genome wide miRNA sequencing, Dr. Mittal and his research team found in human samples of triple negative breast cancer that miR-708 was significantly down-regulated with its normal expression curtailed. In both laboratory cells and in animal studies, the researchers identified that the normal role of miR-708 is to suppress the protein neuronatin, which is located on the membrane of a cell's endoplasmic reticulum -- an organelle that stores calcium. Neuronatin helps control how much calcium leaves that organelle.
"It is calcium that provides legs to cancer cells to help them escape a tumor. So miR-708 acts as a suppressor of metastasis by keeping neuronatin in check," Dr. Mittal says. "If miR-708 is itself suppressed, there is an increase in production of neuronatin proteins, which then allows more calcium to leave the endoplasmic reticulum and activate a cascade of genes that turn on migratory pathways leading to metastasis."
Researchers found that delivering synthetic miR-708, carried by bubbles of fat, blocked metastatic outgrowth of triple negative breast cancer cells in the lung of mice. This makes miR-708 a promising therapeutic against metastatic breast cancer. The researchers also discovered that polycomb repressor complex proteins are responsible for silencing miR-708. These proteins remodel the way DNA is packaged in order to epigenetically silence genes.
Dr. Mittal adds that the findings suggest that pharmacological agents now being tested in lymphoma cancer cells may also help to restore miR-708 in triple negative breast cancer. These drugs are designed to inhibit histone-lysine N-methyltransferase EZH2, the member of the polycomb group that directly silences miR-708.
"It is exciting that there are now drugs that can turn off the silencing of these critical genes. They could very well work for this aggressive breast cancer," says Dr. Mittal. "Finding that there may be a way to shut down the spread of an aggressive breast cancer -- which is the only way that triple negative breast cancer can be controlled and lives spared -- is very promising."
"These study results are terrific," says co-author Dr. Linda Vahdat, director of the Breast Cancer Research Program, chief of the Solid Tumor Service and professor of medicine at Weill Cornell Medical College and medical oncologist at the Iris Cantor Women's Health Center at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. "It not only offers us an avenue to treat metastatic triple negative breast cancer in the short-term, but also gives us the roadmap to prevent metastases in the long-run. We are anxious to get this into the clinic and are working as quickly as possible towards that end."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/USqDCXW_AHw/130114124930.htm
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Niedermayer retired from the NHL on June 22, 2010 and remained with the Ducks as a hockey operations consultant. He will join Bruce Boudreau's coaching staff immediately.
"I'm very excited to expand my role with the Ducks and take on a new challenge," said Niedermayer. "I'm grateful to Bob Murray, Bruce Boudreau and the Ducks organization for giving me this opportunity and can't wait to get started."
The 39-year-old Niedermayer spent the final five seasons of his career with the Ducks after 12 full seasons and part of another with the New Jersey Devils. He won three Stanley Cup titles with New Jersey and led the Ducks to the championship in the spring of 2007 while winning the Conn Smythe Trophy as playoff MVP.
Selected by the Devils with the third overall pick of the 1991 draft, behind Eric Lindros and Pat Falloon, Niedermayer made his NHL debut during the '91-92 season at age 18 and became a mainstay of the New Jersey blue line the following year. He helped the Devils to Stanley Cup titles in 1995, 2000 and 2003 and played one more season in New Jersey, winning his only Norris Trophy as the league's best defenseman in 2004, before moving on to Anaheim.
"As a player, Scott was one of the great leaders and winners of all time, making him a tremendous addition to our coaching staff," said Ducks executive vice president/general manager Bob Murray. "His knowledge of the game and relationship with the players will be a great benefit for us. And he's even a better person than a hockey player."
In addition to his Cup triumphs, Niedermayer also won Olympic gold medals with Canada at the 2002 and 2010 Games and has been a part of title teams at the World Championship, World Cup, Memorial Cup and World Juniors -- making him the only player in history with all six championships.
Niedermayer was selected to the All-Star Game six times, missing one contest because of injury, and was a First-Team NHL All-Star in 2004, 2006 and 2007 with a Second-Team selection in 1998.
In 1,263 regular-season games, Niedermayer scored 172 goals and added 568 assists for 740 points. He added 25 goals and 73 assists for 98 points in 202 playoff games.
Source: http://www.mysportsbook.ag/news/sports_betting/1052057.html
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Source: http://video.msnbc.msn.com/cnbc/50461960/
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Source: http://www.kmvt.com/news/regional/186471161.html
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If you're not keen on giving your little tyke the latest and greatest in terms of smartphones, but still want them to be a call away, the VivoPlay could fit the bill. Evado Filip US, the company behind the device, is packing GPS, WiFi and a GSM connection into a wristwatch form factor, which it claims is the world's smallest communications and location device for helping families stay in touch. Parents can call the device and chat with kids and even give their rug rats the option to call up five pre-selected phone numbers. If a child were to wander away with the VivoPlay on their wrist, parents are alerted if they leave or enter a geofenced area and can pinpoint them on a map via a smartphone app. Were a youngster to find themselves in an emergency, they can hit a button that will ring up to five predefined numbers and report their location. The idea sure is a noble one, and the devices we saw looked more than child-friendly. Evado Filip reps told us that the device is being crafted with just that in mind, and the chunky rubber enclosing the communicator sure bears that out. The charger is enclosed for that reason as well, offering a decent bit of protection from the elements (and from childhood).
There's no word on pricing or availability, but we're told the outfit is working with carriers and that pre-orders will begin in Q2. Check out the neighboring gallery or hit the jump for the full press release.
Filed under: Misc
Source: http://www.engadget.com/2013/01/08/vivoplay-packs-wifi-gps-gsm-phone-kid-tracker/
If you'd like to send me photos to include in next week's "pets on furniture" post, please ensure your photos follow my basic rules: First, the pet must be on a piece of furniture. And?said piece of furniture must be clearly visible in the photo, so it takes center stage rather than your pet.?Think of it more of a photo of a great piece of furniture that you want to show off...and your pet happens to be sitting on it. And second, the photo must be of?decent quality.?If it's dark or fuzzy then it may not make the cut. Photos, your name, location and a brief description can be sent to desiretoinspirekim@hotmail.com and?PLEASE don't send closeups of your pet!?Thanks!
I received a pet entry from Annik that included so many photos of her pets - mostly rescued cats and dogs that she fosters - that I thought these animals needed their own post. Annik's home is beautiful, and the animals she has saved look like they are living the easy-going life they finally deserve.?
Source: http://www.desiretoinspire.net/blog/2013/1/7/mondays-pets-on-furniture-part-2.html
Not all books on negotiation skills cover how to handle internal dissension or conflict during important negotiations. There?s a reason we included it as the third of K&R?s Six Principles? of Negotiation: A team divided is a costly team.
Here is an example of how one of our seasoned negotiation consultants, ?Hank,? handled a very difficult situation with a member of his own team before joining us at K&R.
Hank?s client had put together a strong team to negotiate a deal with an Israeli company. This was one of his client?s biggest deals ever in the country; huge commissions were riding on it. The client had a local negotiator in Israel who was very talented, but also very strong-willed. We?ll call him ?Attila.? As a result of his inability to be flexible when necessary, the deal was stalling. Hank was called in to take over the lead negotiator role.
Hank met with the entire client team in Israel. After assessing the situation, he formulated an updated negotiation strategy. It was clearly explained to Attila that Hank was now in charge and that Attila would take the important second chair. When conducting our meetings with the customer, all information was to be funneled through Hank. Attila agreed to this approach. On the way to the first meeting, Attila was reminded that he had an important role?to cover the financials?but that Hank would take the lead. It was repeated four times. Attila agreed four times.
We walked into the meeting room and Attila sat four seats away from Hank despite the explicit understanding that Attila was to man the second chair. Hank?s team sat down anyway and explained the roles of everybody from their team.
Just a few minutes after the other side?s lead negotiator began speaking, Attila interrupted him. Hank stopped him after a few words, politely explaining that our client was speaking and not to interrupt him. A few minutes later, Attila interrupted the client again. The third time he did it, Hank stopped him at the first word. Attila jumped up and stormed out of the room. Attila did not yet know Hank?s approach or skills well enough; he also had a huge commission riding on the outcome. Nonetheless, we had to manage this internal conflict to not only keep order and focus, but maintain credibility with the other side and the rest of our team.
The team across the table smiled when they saw that Hank and his team were going to proceed without Attila. As negotiations unfolded over the following days, Attila was kept in the loop as to the latest developments, but out of the meetings. Over this time, Attila realized he was wrong and overcame his misgivings about Hank?s approach to the process. The following week, Attila was ready to rejoin the meetings. He lent his particular expertise and helped the team close the deal.
While this situation was awkward, we had to stick to rules and expectations as communicated. This preserved our credibility with the client. Even Attila became our ally when he saw that we were negotiating wisely.
It is the lead negotiator?s job to set rules while reconciling individual and team goals. As this story illustrates, you must negotiate to individual motivations both internally and externally. It is essential that you and your team present a unified voice to the other side. Get those internal conflicts resolved first, or you are not ready to engage the other side in negotiation.
Source: http://www.business2community.com/strategy/negotiation-examples-managing-internal-conflict-0368811
Surprise! If you reasonably believe an employee who?s out on FMLA leave broke a workplace rule, you can fire him?even if it turns out you were wrong.
Recent case: Instead of showing up for an overtime assignment, Joe took intermittent FMLA leave to care for his sick child. A co-worker had told his boss that Joe was planning to go to a casino that day, so the company suspended Joe pending an investigation. Then it spoke with several employees, who all reported that Joe was planning the casino trip and had encouraged them to call in, too.
Joe was terminated and sued, alleging he never went to the casino.
The court said that was irrelevant. His employer investigated the casino rumor and believed it true, which was good reason to fire Joe. (Pulczinski v. Trinity Structural Towers, No. 11-2585, 8th Cir., 2012)
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